Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
125 mcg
625%
Top Medical Research Studies
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
9
We explored the prevalence of diffuse hair loss, specifically telogen effluvium (TE), and the effectiveness of oral vitamin D therapy in treating this issue among women in southern Punjab, Pakistan. Our study involved 40 adult women who received 200,000 IU of vitamin D every two weeks for three months.
After treatment, we assessed the participants' hair growth condition 15 days following their last dose. We found that the average age of the women was 32.2 years, with the age group of 21-30 exhibiting a higher prevalence of TE than those aged 31-40.
Remarkably, 82.5% of the women experienced significant improvement in hair growth after the treatment. We observed that younger women who do not use sunscreen but often consume milk or milk protein showed particularly notable results. This suggests that vitamin D could be a promising option for those struggling with hair loss due to TE.
After treatment, we assessed the participants' hair growth condition 15 days following their last dose. We found that the average age of the women was 32.2 years, with the age group of 21-30 exhibiting a higher prevalence of TE than those aged 31-40.
Remarkably, 82.5% of the women experienced significant improvement in hair growth after the treatment. We observed that younger women who do not use sunscreen but often consume milk or milk protein showed particularly notable results. This suggests that vitamin D could be a promising option for those struggling with hair loss due to TE.
9
We observed how vitamin D3 may influence hair loss in individuals suffering from trichotillomania, a condition characterized by the compulsive urge to pull out hair. The study focused on two female patients who were experiencing noticeable hair loss on their scalps, assessed using the Massachusetts General Hospital Hair Pulling Scale.
To promote hair growth, both patients were given dietary supplementation of vitamin D3 at a dose of 1000 IU daily. Over a treatment period of 3 to 4 months, we noted significant improvements in both patients. This was evidenced by a reduction in hair loss linked to their obsessive-compulsive disorder, which corresponded with increases in their serum 25-hydroxyvitamin D levels.
The results suggest there's a potential connection between vitamin D deficiency and trichotillomania, particularly how inadequate vitamin D may exacerbate hair loss in those susceptible to this disorder. Overall, we found support in both experimental and clinical evidence for the role vitamin D may play in hair loss associated with trichotillomania.
To promote hair growth, both patients were given dietary supplementation of vitamin D3 at a dose of 1000 IU daily. Over a treatment period of 3 to 4 months, we noted significant improvements in both patients. This was evidenced by a reduction in hair loss linked to their obsessive-compulsive disorder, which corresponded with increases in their serum 25-hydroxyvitamin D levels.
The results suggest there's a potential connection between vitamin D deficiency and trichotillomania, particularly how inadequate vitamin D may exacerbate hair loss in those susceptible to this disorder. Overall, we found support in both experimental and clinical evidence for the role vitamin D may play in hair loss associated with trichotillomania.
Most Useful Reviews
9
Strengthened immunity
For many years, I’ve taken vitamin D daily, varying from 2500 to 5000 units, and I trust this manufacturer's additives. Vitamin D benefits me with hair loss, strengthens my immunity, and enhances calcium absorption, all without additional calcium.
7.5
Effective for hair loss
Of all the vitamins D, this one notably aided my hair loss when combined with vitamin K.
7.5
Mood improvement
I started vitamin D based on my endocrinologist’s advice due to a deficiency. I take two small capsules daily, which are easy for anyone to swallow. About a month in, I've observed much less hair loss around my home, and my mood has improved. I’ll retest my vitamin D levels soon.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8
- All Researches
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
9
We explored the potential of vitamin D3, particularly its active form calcitriol, in treating various types of hair loss, including alopecia totalis, universalis, and focalis. Our focus was on three young girls who had battled with severe hair loss for extended periods without success in previous treatments.
Over the course of the study, we initiated a regimen that started with a six-month course of vitamin D3 repletion using oral cholecalciferol, which did not yield immediate results. However, upon switching to calcitriol and its analog, paricalcitol, two out of the three girls experienced significant hair regrowth. One girl saw hair begin to regrow within six months, and her progress stabilized over the next four years with increased doses.
The second patient faced some side effects, such as mild hypercalcemia when taking calcitriol, which we successfully managed by transitioning to paricalcitol. Meanwhile, our third patient experienced a rapid resolution of hair loss with a high dose of cholecalciferol. These findings suggest that vitamin D may hold promise as a therapeutic option in managing specific types of alopecia, warranting further study in larger clinical trials.
Over the course of the study, we initiated a regimen that started with a six-month course of vitamin D3 repletion using oral cholecalciferol, which did not yield immediate results. However, upon switching to calcitriol and its analog, paricalcitol, two out of the three girls experienced significant hair regrowth. One girl saw hair begin to regrow within six months, and her progress stabilized over the next four years with increased doses.
The second patient faced some side effects, such as mild hypercalcemia when taking calcitriol, which we successfully managed by transitioning to paricalcitol. Meanwhile, our third patient experienced a rapid resolution of hair loss with a high dose of cholecalciferol. These findings suggest that vitamin D may hold promise as a therapeutic option in managing specific types of alopecia, warranting further study in larger clinical trials.
9
We explored the prevalence of diffuse hair loss, specifically telogen effluvium (TE), and the effectiveness of oral vitamin D therapy in treating this issue among women in southern Punjab, Pakistan. Our study involved 40 adult women who received 200,000 IU of vitamin D every two weeks for three months.
After treatment, we assessed the participants' hair growth condition 15 days following their last dose. We found that the average age of the women was 32.2 years, with the age group of 21-30 exhibiting a higher prevalence of TE than those aged 31-40.
Remarkably, 82.5% of the women experienced significant improvement in hair growth after the treatment. We observed that younger women who do not use sunscreen but often consume milk or milk protein showed particularly notable results. This suggests that vitamin D could be a promising option for those struggling with hair loss due to TE.
After treatment, we assessed the participants' hair growth condition 15 days following their last dose. We found that the average age of the women was 32.2 years, with the age group of 21-30 exhibiting a higher prevalence of TE than those aged 31-40.
Remarkably, 82.5% of the women experienced significant improvement in hair growth after the treatment. We observed that younger women who do not use sunscreen but often consume milk or milk protein showed particularly notable results. This suggests that vitamin D could be a promising option for those struggling with hair loss due to TE.
9
We observed how vitamin D3 may influence hair loss in individuals suffering from trichotillomania, a condition characterized by the compulsive urge to pull out hair. The study focused on two female patients who were experiencing noticeable hair loss on their scalps, assessed using the Massachusetts General Hospital Hair Pulling Scale.
To promote hair growth, both patients were given dietary supplementation of vitamin D3 at a dose of 1000 IU daily. Over a treatment period of 3 to 4 months, we noted significant improvements in both patients. This was evidenced by a reduction in hair loss linked to their obsessive-compulsive disorder, which corresponded with increases in their serum 25-hydroxyvitamin D levels.
The results suggest there's a potential connection between vitamin D deficiency and trichotillomania, particularly how inadequate vitamin D may exacerbate hair loss in those susceptible to this disorder. Overall, we found support in both experimental and clinical evidence for the role vitamin D may play in hair loss associated with trichotillomania.
To promote hair growth, both patients were given dietary supplementation of vitamin D3 at a dose of 1000 IU daily. Over a treatment period of 3 to 4 months, we noted significant improvements in both patients. This was evidenced by a reduction in hair loss linked to their obsessive-compulsive disorder, which corresponded with increases in their serum 25-hydroxyvitamin D levels.
The results suggest there's a potential connection between vitamin D deficiency and trichotillomania, particularly how inadequate vitamin D may exacerbate hair loss in those susceptible to this disorder. Overall, we found support in both experimental and clinical evidence for the role vitamin D may play in hair loss associated with trichotillomania.
8
We explored the effectiveness of vitamin D3 in treating alopecia areata (AA), a condition that leads to hair loss. To do this, we conducted a study with 75 participants, dividing them into three groups. One group received microneedling treatment alone, while the other two groups received microneedling combined with either topical vitamin D3 or bimatoprost, a drug known to promote hair growth.
Throughout the study, we measured participants' progress using clinical evaluations and a scoring system to gauge hair regrowth. Interestingly, both the vitamin D3 and bimatoprost groups showed significant improvements in hair regrowth compared to the microneedling-only group. However, after three months, we found no notable difference between the regrowth achieved with vitamin D3 and that with bimatoprost.
Importantly, all treatments were well tolerated, with only mild and temporary side effects reported. This leads us to conclude that while vitamin D3 in combination with microneedling offers a promising approach for localized AA, its benefits may not be significantly greater than those of bimatoprost.
Throughout the study, we measured participants' progress using clinical evaluations and a scoring system to gauge hair regrowth. Interestingly, both the vitamin D3 and bimatoprost groups showed significant improvements in hair regrowth compared to the microneedling-only group. However, after three months, we found no notable difference between the regrowth achieved with vitamin D3 and that with bimatoprost.
Importantly, all treatments were well tolerated, with only mild and temporary side effects reported. This leads us to conclude that while vitamin D3 in combination with microneedling offers a promising approach for localized AA, its benefits may not be significantly greater than those of bimatoprost.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strengthened immunity
For many years, I’ve taken vitamin D daily, varying from 2500 to 5000 units, and I trust this manufacturer's additives. Vitamin D benefits me with hair loss, strengthens my immunity, and enhances calcium absorption, all without additional calcium.
7.5
Effective for hair loss
Of all the vitamins D, this one notably aided my hair loss when combined with vitamin K.
7.5
Mood improvement
I started vitamin D based on my endocrinologist’s advice due to a deficiency. I take two small capsules daily, which are easy for anyone to swallow. About a month in, I've observed much less hair loss around my home, and my mood has improved. I’ll retest my vitamin D levels soon.
7.5
Essential for health
Excellent. Vitamin D3 is crucial for our health. Each capsule contains 5000 units, an adequate preventive dose for adults, and they are small and easy to consume. Vitamin D contributes to our immune system and bone health, and it also aids with hair loss. To obtain this vitamin naturally, one must soak up the sun, which we often neglect, leading us to rely on supplements.
7.5
Positive effects noted
Received in good condition. After a week of intake, I haven’t noticed any negative effects and seek to reduce my hair loss with Vit D3.
Frequently Asked Questions
7.5
Mood improvement
I started vitamin D based on my endocrinologist’s advice due to a deficiency. I take two small capsules daily, which are easy for anyone to swallow. About a month in, I've observed much less hair loss around my home, and my mood has improved. I’ll retest my vitamin D levels soon.
7.5
Effective for hair loss
Of all the vitamins D, this one notably aided my hair loss when combined with vitamin K.
6
Reduced hair loss
I have a vitamin D deficiency, so I consume it regularly. I chose this brand for its pure composition, which alleviated many symptoms, including hair loss and increased my energy levels.
9
Strengthened immunity
For many years, I’ve taken vitamin D daily, varying from 2500 to 5000 units, and I trust this manufacturer's additives. Vitamin D benefits me with hair loss, strengthens my immunity, and enhances calcium absorption, all without additional calcium.
7.5
Essential for health
Excellent. Vitamin D3 is crucial for our health. Each capsule contains 5000 units, an adequate preventive dose for adults, and they are small and easy to consume. Vitamin D contributes to our immune system and bone health, and it also aids with hair loss. To obtain this vitamin naturally, one must soak up the sun, which we often neglect, leading us to rely on supplements.
7
We explored the relationship between vitamin D3 levels and diffuse hair loss among a sample of 120 patients in a dermatology clinic. Participants, both male and female, reported losing over 100 strands of hair daily and observed positive results from a hair pull test.
Through our analysis, we found that a staggering 79.17% of these individuals were vitamin D3 deficient. The average vitamin D3 level among the patients was just 17.33 ng/ml. Most of the patients were under 30 years old, indicating that this issue may affect younger adults significantly.
Interestingly, vitamin D3 deficiency was particularly noted in various types of hair loss, including female and male pattern hair loss, diffuse alopecia areata, and telogen effluvium.
This study emphasizes the importance of recognizing and treating vitamin D3 deficiency, especially in patients experiencing diffuse hair fall. By addressing these nutritional gaps, we may offer a viable pathway to help reduce hair loss in affected individuals.
Through our analysis, we found that a staggering 79.17% of these individuals were vitamin D3 deficient. The average vitamin D3 level among the patients was just 17.33 ng/ml. Most of the patients were under 30 years old, indicating that this issue may affect younger adults significantly.
Interestingly, vitamin D3 deficiency was particularly noted in various types of hair loss, including female and male pattern hair loss, diffuse alopecia areata, and telogen effluvium.
This study emphasizes the importance of recognizing and treating vitamin D3 deficiency, especially in patients experiencing diffuse hair fall. By addressing these nutritional gaps, we may offer a viable pathway to help reduce hair loss in affected individuals.
7
We explored the effectiveness of intralesional vitamin D3 as a treatment for patchy alopecia areata (AA). This study involved 40 adult participants divided into two groups: one group received vitamin D3 injections, while the other received triamcinolone acetonide injections, both administered every four weeks for up to three sessions.
Our observations included clinical and trichoscopic evaluations at the start of treatment, after each injection, and three months following the treatment sessions. While both treatments showed a significant reduction in AA-specific trichoscopic signs, there was no statistically significant difference in the overall improvement between the two groups.
Interestingly, while both treatments were similarly effective, patients reported fewer adverse effects and greater satisfaction with the vitamin D3 injections. This points to the potential of vitamin D3 as a simpler, safer, and cost-effective option for patients dealing with patchy hair loss. Overall, our findings suggest that intralesional vitamin D3 could indeed be a promising alternative in treating alopecia areata.
Our observations included clinical and trichoscopic evaluations at the start of treatment, after each injection, and three months following the treatment sessions. While both treatments showed a significant reduction in AA-specific trichoscopic signs, there was no statistically significant difference in the overall improvement between the two groups.
Interestingly, while both treatments were similarly effective, patients reported fewer adverse effects and greater satisfaction with the vitamin D3 injections. This points to the potential of vitamin D3 as a simpler, safer, and cost-effective option for patients dealing with patchy hair loss. Overall, our findings suggest that intralesional vitamin D3 could indeed be a promising alternative in treating alopecia areata.
9
This study dives into how 1,25-(OH)D, a potent form of vitamin D, influences hair growth. Through a combination of experiments in live mice, hair follicle organ culture, and detailed cellular investigations, we uncovered that this vitamin enhances hair regeneration.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
Specifically, we found that 1,25-(OH)D not only extends the growth phase of hair follicles but also improves the abilities of certain skin cells that are vital for hair growth. This process relies on receptors for vitamin D, highlighting the importance of our body’s biological pathways in managing hair health.
Interestingly, our findings showed that 1,25-(OH)D can also negate some of the negative effects of DHT—a hormone often linked to hair loss. Overall, this suggests that vitamin D3 could be an effective treatment option for those experiencing androgenetic alopecia, or common hair loss.
7
We conducted a study to investigate how a vitamin D analogue, calcipotriol, affects hair loss in patients with alopecia areata (AA). A total of 22 individuals participated in this prospective study, applying calcipotriol lotion at a concentration of 0.005% twice daily over three months.
Throughout the study, we closely monitored the patients, measuring their hair regrowth every month at intervals of 4, 8, and 12 weeks. At the end of the treatment period, 59.1% of the participants showed signs of hair regrowth. Interestingly, we observed that the average time for stabilization and regrowth was around four weeks.
Additionally, we noted that the response to treatment was particularly effective among patients with lower serum vitamin D levels. This suggests that using topical calcipotriol might be a valuable alternative for those experiencing vitamin D deficiency, especially in managing alopecia areata. We believe our findings could open new avenues for treating hair loss in patients struggling with this condition.
Throughout the study, we closely monitored the patients, measuring their hair regrowth every month at intervals of 4, 8, and 12 weeks. At the end of the treatment period, 59.1% of the participants showed signs of hair regrowth. Interestingly, we observed that the average time for stabilization and regrowth was around four weeks.
Additionally, we noted that the response to treatment was particularly effective among patients with lower serum vitamin D levels. This suggests that using topical calcipotriol might be a valuable alternative for those experiencing vitamin D deficiency, especially in managing alopecia areata. We believe our findings could open new avenues for treating hair loss in patients struggling with this condition.
References
- Jalil P, Masood S, Sadique M, Jalil MA, Jalil M, et al. Filling the Gaps: Vitamin D Status in Diffuse Hair Fall Among Pakistanis. Dermatol Pract Concept. 2024;14. doi:10.5826/dpc.1404a232
- Ragaie MH, Mohammed SE, Shehata SS. Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study. J Cosmet Laser Ther. 2024;26:89. doi:10.1080/14764172.2024.2389275
- Zong X, Yang S, Tang Z, Li X, Long D, et al. 1,25-(OH)D promotes hair growth by inhibiting NLRP3/IL-1β and HIF-1α/IL-1β signaling pathways. J Nutr Biochem. 2024;132:109695. doi:10.1016/j.jnutbio.2024.109695
- Meguid AMA, Ghazally A, Ahmed AM, Bakr RM. Fractional carbon dioxide laser alone and as an assisted drug delivery for treatment of alopecia areata: a clinical, dermoscopic and immunohistochemical study. Arch Dermatol Res. 2023;315:1675. doi:10.1007/s00403-023-02565-x
- Ali MS, Hafiz HSA, Ahmed NA, Galal SA. Combined microneedling with topical vitamin D3 or bimatoprost versus microneedling alone in the treatment of alopecia areata: A comparative randomized trial. J Cosmet Dermatol. 2023;22:1286. doi:10.1111/jocd.15569
- Papadimitriou DT, Bothou C, Dermitzaki E, Alexopoulos A, Mastorakos G. Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs: Three case reports and a literature review. World J Clin Pediatr. 2021;10:192. doi:10.5409/wjcp.v10.i6.192
- Sattar F, Almas U, Ibrahim NA, Akhtar A, Shazad MK, et al. Efficacy of Oral Vitamin D Therapy in Patients Suffering from Diffuse Hair Loss (Telogen Effluvium). J Nutr Sci Vitaminol (Tokyo). 2021;67:68. doi:10.3177/jnsv.67.68
- Titus-Lay E, Eid TJ, Kreys TJ, Chu BXJ, Malhotra A. Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report. Ment Health Clin. 2020;10:38. doi:10.9740/mhc.2020.01.038
- Nayak K, Garg A, Mithra P, Manjrekar P. Serum Vitamin D Levels and Diffuse Hair Fall among the Student Population in South India: A Case-Control Study. Int J Trichology. 2016;8:160. doi:10.4103/ijt.ijt_57_16
- Narang T, Daroach M, Kumaran MS. Efficacy and safety of topical calcipotriol in management of alopecia areata: A pilot study. Dermatol Ther. 2017;30. doi:10.1111/dth.12464
